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Chemotherapy was potentiated by E7449 and one agent had sizeable antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/?-catenin signaling in colon cancer mobile strains, very likely by means of TNKS inhibition. In step with this chance, E7449 stabilized axin and TNKS proteins causing ?-catenin de-stabilization and signi… Read More